Basic informations

Investigator: prof. MUDr. Pavel Mohr, Ph.D.
Main recipient: National Institute of Mental Health (NIMH)
Research period: 1/1./2020 - 31/12/2022
Total budget: 7,731,000 CZK
Supported by: Czech Science Foundation (GAČR)

Annotation

The ability of identifying and distinguishing one's own actions from the external processes (Self / Other Agency) is a key prerequisite for one's orientation in the world and society. Proposed project builds upon results of our previous fMRI experiments both on healthy participants and schizophrenia patients. Here, using the combination of dynamical causal modeling (DCM) and noninvasive brain neuromodulation (tACS), we aim for confirming the causal role of inferior parietal lobe (IPL) in Self / Other Agency discrimination. Project is divided into five steps, starting with identifying the candidate subregion within IPL based on contrast analysis and DCM on the MRI data obtained in experiments realized earlier. Following will be an explorative and confirmatory neuromodulation experiments, aiming for confirming the causal role of identified region by targeted external neuromodulation. Comparison of pre- and post- neuromodulation resting state MRI will verify the effective locus of neuromodulation protocol.