Prof. Saak Victor Ovsepian, M.D., Ph.D.
head of research programme
working at:  RP1 Experimental Neurobiology
in the institution:  2018 - present
telephone: (+420) 283 088 242
e-mail: Saak.Ovsepian@nudz.cz
curriculum vitae


Selected publications

Ovsepian SV et al., Advances in Optoacoustic Neurotomography of Animal Models. Trends Biotechnol. 2019 pii:S0167-7799(19)30186-6. doi: 10.1016/j.tibtech.2019.07.012. IF=13.7

Olefir I et al. Spatial and spectral mapping and decomposition of neural dynamics and organization of the mouse brain with multispectral optoacoustic tomography. Cell Reports. 2019 Mar 5;26(10)2833-2846. doi: 10.1016/j.celrep.2019.02.020. IF=8.3  

Ovsepian SV. Dark matter of the brain. Brain Structure and Function. 2019 Jan 18. doi: 10.1007/s00429-019-01835-7. IF=4.3

Ovsepian SV et al. Synaptic vesicle cycle and Aβ: biting the hand that feeds. Alzheimer’s and Dementia, 2018. doi: 10.1016/j.jalz.2018.01.011; 2018. IF=13.2 

Ovsepian SV et al., Neurobiology and therapeutic applications of neurotoxins targeting transmitter release. Pharmacol Ther. 2018. doi: 10.1016/j.pharmthera.2018.08.016. IF=12.2

Ovsepian SV et al. Pushing the boundaries of neuroimaging with optoacoustics. Neuron 2017. doi: 10.1016/j.neuron.2017; IF 14.1

Ovsepian SV et al.  Ambient glutamate promotes paroxysmal hyperactivity in cortical pyramidal cells at amyloid plaques via presynaptic mGluR1 receptors. Cerebral Cortex, 2017. doi: 10.1093/cercor/bhw267. IF: 8.2

Ovsepian SV et al. Circumventing Brain Barriers: Nanovehicles for Retro-axonal Therapeutic Delivery. Trends in Mol. Medicine 2016; doi:10.1016/j.molmed.2016.09.004. IF: 10.8

Ovsepian SV et al. Distinctive role of KV1.1 subunit in the biology and functions of low threshold KV1 channels with implications for neurological disease. Pharmacol Ther. 2016, doi: 10.1016/j.pharmthera.2016.01.005. IF: 11.1

Willem M et al. η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature, 2015 Doi:10.1038 / 14864. IF: 38.1

Ovsepian SV et al. Cholinergic Mechanisms in the Cerebral Cortex: Beyond Synaptic Transmission. Neuroscientist, 2015. doi: 10.1177/1073858415588264. IF: 7.4

Ovsepian SV et al. Pharmacological inhibition of BACE1 can impair dendritic spine formation and synaptic plasticity and lead to a specific cognitive deficit. Biol. Psychiatry, 2014. doi: 10.1016/j.biopsych.2014.10.013. IF: 11.2

Ochs S et al. Loss of neuronal GSK3 beta reduces dendritic spine stability and alters synaptic transmission via beta-catenin. Mol. Psychiatry, 2014.  doi: 10.1038/mp.2014.55. IF: 14.4

Neuner J et al. Pathological α-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb. Nature Comm. 2014. doi: 10.1038/ncomms4915. IF: 11.3

Ovsepian SV & Dolly JO. Dendritic SNAREs add a new twist to the old neuron theory. Proc. Nat. Acad. Sci. 2011, doi: 10.1073/pnas.1017235108. IF: 9.4

Professional training and experience

1999 - 2003: Ph.D. at the Institute of Brain Physiology and Biochemistry, Saint Petersburg, Russian Federation
2003 - 2005: Postdoctoral Fellow at the Department of Pharmacology & Therapeutics, Trinity College Dublin Institute of Neuroscience, Dublin, Republic of Ireland
2005 - 2008: Research Associate at the Centre for Molecular and Behavioral Neuroscience, State University of New Jersey Rutgers, Newark, New Jersey, USA
2008 - 2012: Group Leader at the International Centre for Neurotherapeutics, Dublin City University, Republic of Ireland
2008 - 2012: Science Foundation Ireland Research Fellow; Founding Director of the National Core Imaging Facility in the International Centre for Neurotherapeutics, Republic of Ireland
2012 - 2015: Senior Investigator, Director of Electrophysiology at DZNE Munich & Centre for Neuropathology and Prion Research at LMU, Germany
2013 - 2018: Adjunct Professor at the International Centre for Neurotherapeutics, Dublin City University, Republic of Ireland
2015 - 2018: Senior Neuroscience Investigator at IBMI-HMGU and at Chair of the Biological Imaging at TUM, Munich, Germany
2018 - 2018: Adjunct Neuroscience Investigator at the Institute of Biological and Medical Imaging, Helmholtz Zentrum Munich, Germany
2018 - 2018: Head of the Experimental Neurobiology at the National Institute of Mental Health, Klecany, Czech Republic

Teaching activities

2008 - 2012: Targeting and axonal delivery of therapeutics to the central nervous system
2008 - 2012: PRTLI4 lecture series: molecular biology of synapses and neurons. Physiology and pharmacology of ion channels and ion channel disease
2009 - 2016: Summer school lectures and seminars: the modes and modalities of contemporary biomedical imaging
2015 - 2018: Introduction to neurobiology and synaptic physiology. Synaptic physiology, adult neurogenesis and neurodegenerative diseas

Publications


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RP1 Experimental Neurobiology RP2 Public Mental Health RP3 Applied Neuroscience and Neuroimaging RP4 Epidemiological and Clinical Research in Addictions RP5 Sleep Medicine and Chronobiology RP6 Brain Electrophysiology RP7 Clinical Research of Mental Disorders RP8 Translational Neuroscience International Cooperation Department AD Centrum Publications Ongoing Projects Pharmaceutical Industry-Sponsored Research Ethics Commission Postgraduate Students Conferences & Seminars Awards International Course 2015
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