Ongoing Projects



OP Research, Development and Education 

Centre for Technology and Knowledge Transfer NIMH (CZ.02.2.69/0.0/0.0/16 014/0000656)
Investigator: RNDr. Karel Valeš, Ph.D., Ing. Šimon Skovajsa
Principle investigator: NIMH 
Duration: 1.7.2016–31.12.2020 
Total budget NIMH: 16 140 904 CZK
Abstract: The Project sets out as its objective setting up and development of a comprehensive system for transferring knowledge into practice in the National Institute for Mental Health, being subsidized from the OP VaVpl PO II Operational Program with the sum of CZK 971 million, by accelerating transfer of the research & development outcomes into application spheres both in the Czech Republic and abroad, and to help in identifying the research & development outcomes and in project development with commercial potentials in the fields of psychiatry, psychology, and neurobiology.

PharmaBrain (CZ.02.1.01/0.0/0.0/16_025/0007444)
Investigator: RNDr. Karel Valeš, Ph.D., Ing. Šimon Skovajsa
Principle investigator: NIMH Co-investigator-Partner: Institute of Physioloogy CAS; Charles University, 3rd Medical Faculty; University of Hradec Králové
Duration: 1.1.2018–31.12.2022
Total budget: 148 262 697 CZK
Total budget NIMH: 78 821 389 CZK
Abstract: The present project focuses on the research of a glutamatergic neurotransmitter system, which under physiological conditions controls a whole range of processes in the brain and participates in the management of normal brain development. At the same time, however, its dysfunction plays a significant role in many neuropsychiatric disorders. The project focuses on its role in both clinical practice and experimental models. This direction of research has a long-standing tradition and a high reputation at an international level in participating workplaces.

Development of Capacities for Research and Development at the NIMH (CZ.02.2.69/0.0/0.0/16_028/0006222)
Investigator: Ing. Tomáš Kopřiva, Alexandr Borovička, DiS.
Principle investigator: NIMH
Duration: 1.1.2018–31.10.2022
Total budget NIMH: 45 405 269 CZK
Abstract: The project of the National Institute of Mental Health (NIMH) focuses on developing the capacities, knowledge and skills of the applicant's managerial, research and other personnel in the field of strategic R&D management, as well as setting up and implementing strategic management within the research organization in accordance with the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers and to Achieve the HR Award.



OP Prague – Growth Pole of The Czech Republic

PoC of Commercialization Concepts Formulated by Innovation Agency ILA II
Investigator: doc. MUDr. Aleš Bartoš, Ph.D.
Principal investigator: ILA s.r.o. Co-investigator-partner: NIMH 
Duration: 1.1.2018–31.12.2020
Total budget: 13 207 787 CZK
Total budget NIMH: 3 725 053 CZK
Abstract: The project of the National Institute of Mental Health focuses on developing the capacities, knowledge and skills of the applicant's managerial, research and other personnel in the field of strategic R&D management, as well as setting up and implementing strategic management within the research organization in accordance with the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers and to Achieve the HR Award.


OP Employment

Destigmatization of People with Mental Disease (CZ.03.2.63/0.0/0.0/15_039/0007276)
Investigator: PhDr. Petr Winkler
Principle investigator: NIMH 
Duration: 1.9.2017–31.8.2022
Total budget NIMH: 94 956 515 CZK
Abstract: The project improves the quality of life of people with mental illness through a range of destigmatization measures. It builds on the best foreign and domestic experience, careful situational analysis, cooperation with the world leading experts, a wide participation of people with mental illness and their loved ones and an expert platform bringing together representatives of psychiatric care in the Czech Republic. The project includes continuous evaluation of the effectiveness of the measures.

Early Intervention for Serious Mental Illness (VIZDOM) (CZ.03.2.63/0.0/0.0/15_039/0009304) Investigator: PhDr. Petr Winkler
Principle investigator: NIMH
Duration: 1.4.2018–31.3.2022
Total budget NIMH: 37 319 716
Abstract: The project presented in the framework of the reform of mental health care will increase the availability and efficiency of health and social services and support the transfer of the centre of psychiatric care to the community. It is aimed at supporting prevention and early intervention in severe mental illnesses (SMI). It focuses on preventing the development of mental illnesses, reducing the number and length of hospitalizations for the first episodes of SMI, and on preventing the loss of employment in people at risk of SMI. The proposed measures will be implemented and evaluated within the framework of the project.

NIMH Children’s Group (CZ.03.1.51/0.0/0.0/17_073/0008810)
Investigator: prof. MUDr. Cyril Höschl, DrSc., FRCPsych.
Principle investigator: NIMH 
Duration: 1.6.2018–31.5.2020
Total budget NIMH: 2 260 800 CZK

Paraphile Project (CZ.03.3.X/0.0/0.0/15_018/0011540)
Investigator: Mgr. Kateřina Klapilová, Ph.D.
Principle investigator: NIMH 
Duration: 1.9.2019–31.12.2022
Total budget NIMH: 38 389 181 CZK


OP Enterprise and Innovation for Competitivness

Identification of drugs and other substances in the aquatic ecosystem – DrugsLab
Investigator: RNDr. Karel Valeš, Ph.D.
Principle investigator: E&H services a.s.
Co-investigator-Partner: NIMH
Duration: 1.7.2018–31.10.2020
Total budget: 7 889 609 CZK
Total budget NIMH: 1 510 942 CZK
Abstract: The project focuses on methodologies for verification of the use of passive samplers for the  determination of biologically active substances - addictive substances, pharmaceuticals and other similar compounds in the aquatic ecosystems, at various places in the watercourses. Also included in the passive sampler system are SPRi chips that allow genotoxicity to be determined. The resulting methods of modification of passive samplers, sampling methodology, analytical techniques and advanced information analysis using robust results evaluation methods will be developed both in terms of environmental protection and in terms of abuse and illegal consumption of these substances. The result of the project is not only a functional methodology for detection of these substances, but also testing the possibilities and effectiveness of technology for removing substances of interest from various matrices, which is one of the key areas that the authors of the project have been dealing with for a long time. The developed methodologies will be tested in watercourses at sites expected to occur, such as selected wastewater treatment plants or hospitals. The techniques will be ready for immediate use on suspicion of the presence of these substances in the wastewater, whatever the source member.

Development of DNA-biochips for rational prescription of Psychopharmaceuticals (CZ.01.1.02/0.0/0.0/17_107/0012433)
Investigator: RNDr. Karel Valeš, Ph.D.
Principle investigator: ESSENCE LINE, s.r.o
Co-investigator-Partner: NIMH
Duration: 1.1.2018–31.10.2020
Total budget: 11 073 961 CZK
Total budget NIMH: 2 569 868 CZK
Abstract: The aim of the project is to develop a new DNA-biochip for the rationalized prescription of psychopharmaceuticals for patients with psychiatric illness and thereby bring benefits not only to the patient, but to reduce the costs of health insurance companies. The benefit of the project will be a safer and more effective prescription of psychopharmaceuticals, which will lead to more successful pharmacotherapy, increase patient comfort in the form of positive therapy and reduce the cost of inefficiently applied psychopharmaceuticals and negative effects on the patient.

Application of Industrial Biotechnology Methods for Differential Diagnostics of Neurological Diseases (CZ.01.1.02/0.0/0.0/17_176/0015497)
Investigator: RNDr. Jan Říčný, CSc.
Principle investigator: VIDIA spol. s r.o.
Co-investigator-Partner: NIMH
Duration: 1.7.2019–30.6.2022
Total budget: 11 073 961 CZK
Total budget NIMH: 2 569 868 CZK
Abstract: The aim of the project is the development of a multiparametric diagnostic kit and prototypes of autoantibody kits against selected antigens to be used in differential diagnostics, disease evaluation and response to treatment of selected neurological diseases - Alzheimer's disease, Parkinson's disease, Frontotemporal neurodegeneration, Lewy's dementia and Vascular dementia . Although the problems with aging of population is becoming increasingly urgent, there are currently no commercial kits to diagnose these neurodegenerations. The developed highly specific tests will create a new segment of diagnostic kits for use in the global market.

Research and Development of Phototherapy Mask for Seasonal Affective Disorder (CZ.01.1.02/0.0/0.0/17_107/0012517)
Investigator: PhDr. Jana Kopřivová, Ph.D.
Principle investigator: ELON Technologies s.r.o.
Co-investigator/Partner: NIMH
Duration: 1.1.2020–31.10.2020
Total budget: 18 860 156 CZK
Total budget NIMH: 4 564 886 CZK
The aim of the project is to develop a phototherapeutic mask to influence the circadian rhythms. The basic functional principle of the device is based on the technology of printed forms of electroluminescent light in the area of the blue light spectrum (460 - 480 nm). As part of the project we will develop an innovative, user-friendly hardware platform that will be able to detect phase shifts in circadian rhythms based on the user's physical activity. Subsequently, the light mask lighting mode will be individually tailored in order to influence circadian rhythms by retinal illumination during sleep. As a result, a non-invasive phototherapy device for home use by patients will be developed.


Integrated Regional OP

Electronization of Processes in Internal Information Systems of NIMH
Investigator: prof. MUDr. Pavel Mohr, Ph.D., Alexandr Borovička, DiS.
Principle investigator: NIMH
Duration: 1.4.2017–31.12.2020
Total budget NIMH: 57 182 821 CZK
Abstract: The goal of this project is digitalization and formalization of mission critical paper or manual processes within the organization in accordance to National eHealth Strategy of the Czech Republic 2016-2020. The steps include Hospital Information System (HIS) and Picture Archiving and Communication System (PACS) modernization, implementation of central Electronic Document and Record Management System, Enterprise Resource Planning (ERP) system modernization a implementation of identity management. A part of the project also includes creation of integrated IS NIMH through interconnection with integration platform.

eHealth Integrated Psychiatric Care System (IRIS) (CZ.06.3.05/0.0/0.0/16_034/0006455)
Investigator: MUDr. Filip Španiel, Ph.D.
Principle investigator: NIMH
Duration: 1.4.2017–31.12.2021
Total budget NIMH: 98 979 210 CZK
Abstract: eHealth platform IRIS represents  an unique diagnostic, monitoring and networking system in psychiatry, designed to prevent relapse, coordinate psychosocial rehabilitation interventions in patients with psychotic disorders, and at the same time optimize treatment for early stages of psychotic disorders. The aim of project is to design and develop a comprehensive IT-aided system to monitor, analyse and communicate objective and quantitative information pertaining to patients suffering from schizophrenia as well as subjective feedback from the patient himself/herself and those with whom the patient is close (i.e. family, friends, etc). The eHealth Network will be composed of IRIS consortium members including outpatient facilities, community mental health centres, psychiatric hospitals and psychiatric wards affiliated with general hospitals. Proposed system will automatically detect signifiers of episodic relapse through the continuous monitoring of multi-parametric indicators by use of mobile technology and advanced hardware platforms.
Bringing together expert medical and technological expertise, the interdisciplinary research and development based on multi-parametric biomarkers,  we will provide the foundation for the development of a predictive system aimed at subtypization of schizophrenia and predicting treatment response and functional outcome. The main aim is to provide health professionals, observers and patients with an innovative approach for better tertiary prevention and management with particular focus on early stage of the most severe mental diseases. As a first step we will focus on schizophrenia, but will develop a framework applicable to other psychiatric/neurological disorders in the future. Based on these results, we will delineate patient care and regulatory pathways to translate these tools into research and clinical practice, and engage with stakeholders and regulatory bodies to ensure their uptake.




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