RP6 Brain Electrophysiology – Running Grants and Projects



Czech Health Research Council

Obsessive-compulsive Disorder as a Decision-making Disease: Translational Probe of Aberrant Error Signalling and Coordination of Brain Networks Targeting Causal Interactions and Clues for Therapy (NU20-04-00147)
Investigator: prof. MUDr. Jiří Horáček, Ph.D., FCMA
Principle investigator: NIMH
Project partner: Institute of Physiology CAS
Duration: 1.5.2020–31.12.2023
Total budget: 13 941 000 CZK
Total budget NIMH: 8 092 000 CZK
Abstract: Obsessive-compulsive disorder (OCD) is a disabling psychiatric condition characterized by intrusive thoughts and repetitive actions. A substantial part  of OCD patients is refractory to current treatment methods which poses a challenge to the understanding of pathophysiological mechanisms of OCD. This project aims to explore the causal interactions between OCD symptoms, brain structure and function. On the basis of the clinical features of OCD symptoms and brain imaging studies, the project postulates OCD as a decision making disorder resting on altered valuation and probability weighing functions, inflated loss and risk aversion, increased error signalling, and diminished resting state network activations. The neural substrate of the altered decision making will be explored in a set of behavioural, electrophysiological and fMRI decision making experiments in humans, combined with two animal models of OCD including decision making tasks, direct electrical recording (tetrodes) and molecular imaging in rats. The project aims at a translational model of OCD allowing to identify novel therapeutic targets for navigated neurostimulation and other treatment modalities.



RP1 Experimental Neurobiology RP2 Public Mental Health RP3 Applied Neuroscience and Neuroimaging RP4 Epidemiological and Clinical Research in Addictions RP5 Sleep Medicine and Chronobiology RP6 Brain Electrophysiology RP7 Clinical Research of Mental Disorders RP8 Translational Neuroscience International Cooperation Department AD Centrum Publications Ongoing Projects Pharmaceutical Industry-Sponsored Research Ethics Commission Postgraduate Students Conferences & Seminars Awards International Course 2015
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