Animal Models of Neurodevelopmental and Psychiatric diseases

Head of the department

RNDr. Tomáš Petrásek, Ph.D.

The research group of Animal Models of Neurodevelopmental and Psychiatric Disease is a recently established team of researchers, with the main focus on neurodevelopmental and psychiatric disease in animal models. It applies advances neurophysiological and behavioural tools and methods to investigate transgenic and drug-induced conditions mimicking neurological and psychiatric disorders, with the aim of elucidating their molecular and cellular mechanisms. The main focus of the group is on autism, schizophrenia and related mental disorders. A wide range of behavioural tests is applied to interrogate cognitive functions, emotionality, and social interactions in animal studies, along with in-depth analysis of underlying neurochemical and histopathological changes in the brain. An in-depth characterisation of the animal models is performed to define their validity and potential limitations. The ultimate goal is to elucidate the neurobiological mechanisms and define the behavioural correlates of neurodevelopmental diseases in experimental models in order to find new preventive schemes and therapeutic approaches.

Key publications

1. Petrásek, T., Vojtechova, I., Lobellova, V., Popelikova, A., Janikova, M., Brožka, H., ... & Valeš, K. (2018). McGill transgenic rat model of Alzheimer's disease displays cognitive and non-cognitive impairments and altered circadian clock function. Frontiers in aging neuroscience, 10, 250, IF = 3.582

2. Vojtechova, I., Petrasek, T., Maleninska, K., Brozka, H., Tejkalova, H., Horacek, J., ... & Vales, K. (2018). Neonatal immune activation by lipopolysaccharide causes inadequate emotional responses to novel situations but no changes in anxiety or cognitive behavior in Wistar rats. Behavioural brain research, 349, 42-53, IF = 3.173

3. Petrasek, T., Prokopova, I., Sladek, M., Weissova, K., Vojtechova, I., Bahnik, S., ... & Bartsch, D. (2014). Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety, and altered circadian activity patterns. Frontiers in behavioral neuroscience, 8, 90, IF = 3.27

4. Petrasek, T., Skurlova, M., Maleninska, K., Vojtechova, I., Kristofikova, Z., Matuskova, H., ... & Stuchlik, A. (2016). A rat model of Alzheimer’s disease based on Abeta42 and pro-oxidative substances exhibits cognitive deficit and alterations in glutamatergic and cholinergic neurotransmitter systems. Frontiers in aging neuroscience, 8, 83, IF = 4.504

5. Vojtechova, I., Petrasek, T., Hatalova, H., Pistikova, A., Vales, K., & Stuchlik, A. (2016). Dizocilpine (MK-801) impairs learning in the active place avoidance task but has no effect on the performance during task/context alternation. Behavioural brain research, 305, 247-257, IF = 3.002

Team members

Klovrza, Ondřej
Kútna, Viera, RNDr., Ph.D.
Stuchlík, Aleš, prof. RNDr., Ph.D., DSc.
Šmejkalová, Klára
Tučková, Klára
Uttl, Libor, Mgr.
Vojtěchová, Iveta, Mgr.
 


RP1 Experimental Neurobiology RP2 Social Psychiatry RP3 Applied Neurosciences and Brain Imaging RP4 Epidemiological and Clinical Research in Addictions RP5 Sleep Medicine and Chronobiology RP6 Brain Electrophysiology RP7 Diagnostics and Treatment of Mental Disorders RP8 Translational Neuroscience International Cooperation Department AD Centrum Publications Research Projects Pharmaceutical Industry-Sponsored Research Ethics Commission Postgraduate Students Conferences & Seminars Awards International Course 2015
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