Pracovní skupina kognitivních a sociálních neurověd

Cognitive and Social Neuroscience is an emerging scientific discipline that attempts to integrate the theories, methods, and insights of social cognition and cognitive neuroscience. Having complementary focuses, Cognitive Neuroscience moves „downwards“ into the brain, with the aim to relate particular mental abilities (such as working memory, motor abilities, attention) to the structure and function of the nervous system. In contrast, Social Neuroscience moves from the information-processing mechanisms ‘upward” into the phenomenology of the person, exploring social and affective forces that trigger particular behaviours. Using a combination of behavioral testing, advanced brain imaging, and theoretical modeling, the cognitive neuroscience research endeavors seek to elucidate how high-level cognitive and social functions, such as language and motor functions, social cognitive skills are related to specific neural substructures in the brain.

Aims of the group: Brain Imaging technologies are crucial for understanding the relationships between specific areas of the brain and their function, helping to locate the areas of the brain that are affected by neurological or psychiatric disorders and build new strategies to treat them. Schizophrenia is characterized by poor social functions and cognitive impairment. We aim to explore potential mechanisms that might contribute to cognitive and social deficits in schizophrenia.

Current projects

1. Predicitive modeling of cognitive deficits from functional and structural connectivity patterns in schizophrenia.

a) identification of the interrelations of the brain networks and their alterations in schizophrenia.
b) investigation of interconnections between brain networks and cognitive functioning referring to cognitive deficits in schizophrenia.
c) formulation of a comprehensive model of cognitive functioning in schizophrenia (cognitive connectome) reflecting different levels of disruptions: behavioural (cognitive performance) and physiological (brain networks) levels and testing it prospectively.

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2. Neural mechanisms of mirror neurons dysfunction in schizophrenia using multi-modal approach (simultaneous fMRI-EEG, transcranial magnetic stimulation)

a) investigation of the resting state functional connectivity in the predefined brain structures, known for their mirror neurons activity (premotor cortex, inferior frontal gyrus, superiortemporal gyrus, superior parietal lobule) in patients with schizophrenia.
b) application of a variety of tasks (motor, language and social cognitive tasks) as behavioral and fMRI paradigms in patients with schizophrenia and investigations of the common patterns connected to mirror neurons activity
c) application of transcranial magnetic stimulation to cortical areas (above specified) anticipating the increased motor, language and social cognitive tests performance.

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3. Linking phenomenology and neurobiology of auditory hallucinations in schizophrenia:

In the current study, we plan to apply a variety of behavioral and neuroimaging strategies that will assist in explicit characterization of AHs linking between phenomenology and neurobiology. We aim:

1. To provide a comprehensive overview of phenomenology of AHs in schizophrenia, subtypization of AHs using phenomenological questionnaires and cluster analysis.
2. To perform structural morphological analysis and fMRI examination investigating different neurobiological substrate of the detected subtypes of AHs.
3. To evaluate the contribution of the self-disturbances on the phenomenological and neurobiological levels using fMRI paradigms with self-agency task and self/other differentiation tasks.
4. To discriminate subjects with monological and dialogical IS using the VISQ questionnaire and with the use of machine learning (MVPA) and data on the inner speech paradigm from healthy controls to obtain neural characteristics of subjects and test it in patients with and without AH.
5. To unite the phenomenological characteristics of subgroups of patients with AHs (also with different types) and without AH, their functional neurobiological characteristics (inner speech, affective speech attribution, first and third person perspective, dialogic/monologic speech), behavioral and structural brain indices in order to conceptualize potential neural mechanisms of the hallucinations in psychosis.

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Collaborative projects

Department of Psychiatry, Ludwig Maximilian University, Munich, Germany

“Linking social cognition with social interactions in schizophrenia: cognitive, emotional, clinical and biological correlates” - a pilot study aimed at investigating cross cultural specificities of social interactions. The first FMRI experiment will investigate the neural correlates of social interactions derived from individual autobiographical experiences with distinct emotional connotations. The second experiment will examine neural mechanisms of instant interactions with virtual person exhibiting dynamic facial expression that resembles real life approach situation when initiating social interactions.

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Pracovníci

Spolupracující výzkumníci

Monika Kolářová

Julie Melicharová

Lukáš Kutil

Ondřej Havlíček

Stážisté

Členové skupiny

Kolářová, Monika, Ing. Kozáková, Eva, Mgr.
Loginova, Alisa, Bc. Fajnerová, Iveta, Mgr. et Mgr., Ph.D.
Hejtmánek, Lukáš, Mgr. Bendová, Marie, PhDr.
Dvořáček, Boris, MUDr.
 
VP1 Experimentální neurobiologie VP2 Sociální psychiatrie VP3 Aplikované neurovědy a zobrazení mozku VP4 Epidemiologický a klinický výzkum závislostí VP5 Spánková medicína a chronobiologie VP6 Elektrofyziologie mozku VP7 Diagnostika a léčba duševních poruch Centrum transferu technologií a aplikovaného výzkumu NUDZ AD Centrum Publikace Výzkumné projekty Kontrahovaný výzkum Specifické výsledky výzkumu Etická komise Postgraduální studenti Semináře Ceny a ocenění
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