Sleep and brain changes related to memory decline in mild cognitive impairment (NV18-07-00272)

Basic informations

Investigator: prof. MUDr. Aleš Bartoš, Ph.D.
Main recipient: National Institute of Mental Health (NIMH)
Research period: 1/5/2018 - 30/6/2022
Total budget:9 433 000 CZK
Supported by: Czech Health Research Council (AZV ČR)




The expected aging of the population will increase people with memory disease and dementia, especially Alzheimer's disease. Mild cognitive impairment (MCI) is a risk syndrome in which intervention can delay the development of Alzheimer's disease. Sleep disorders and changes in magnetic resonance imaging of the brain occur along with memory impairment in MCI. The aim of the project is to find the connection between slow-wave sleep and sleep spindles, corresponding brain structures and memory consolidation during sleep using polysomnography, magnetic resonance imaging of the brain and paired associative learning test. Then we will investigate whether it is possible to enhance memory consolidation during sleep in MCI by manipulating sleep rhythms using acoustic stimulation. Based on the results, we will illuminate mechanisms between sleep, brain structure, and memory impairment in MCI. This comprehensive sleep approach can bring new insights into early interventions and other clinical strategies at the stage of MCI.