Overlap of neurodegenerative dementias and their clinic-pathological correlations: a prospective-retrospective multicentric study (NV19-04-00090)

Basic informations

Investigator: prof. MUDr. Aleš Bartoš, Ph.D.
Main recipient: Thomayer University Hospital - doc.MUDr. Radoslav Matěj, Ph.D.
Co-recipient: National Institute of Mental Health (NIMH), University Hospital Olomouc - doc. MUDr. Kateřina Menšíková, Ph.D.; Na Homolce Hospital - MUDr. Jiří Keller, Ph.D.; General University Hospital in Prague - Prof. MUDr. Jan Roth, CSc
Research period: 1/5/2019 - 31/12/2022
Total budget: 15,127,000 CZK
NIMH budget: 1,580,000 CZK
Supported by: Czech Health Research Council (AZV ČR)


Neurodegenerative diseases are serious fatal disorders caused by progressive loss of specific neuronal populations.Correct recognition of neurodegenerative dementias during the patients’ life is still very difficult.Combinations of two or more neurodegenerative diseases are far more common than previously admitted, even though more precise epidemiological data is still missing.Overlap of neurodegenerative diseases may be involved into a more rapid progression or very atypical presentation in many patients.Moreover,newly described neuropathological entities related to the aging-Aging-related tau astrogliopathy(ARTAG) or Primary age-related tauopathy(PART)-are more frequent than previously expected and till this time a precise definition of the clinical picture of these impairments is missing.The principal objective is to estimate the proportion of comorbid neurodegenerative dementias in a single centre and in a neuropathological reference laboratory based on retrospective and prospective clinic-pathological correlations in order to improve the clinical diagnosis of different diseases.