MUDr. Monika Klírová, Ph.D.
researcher, physician, lecturer, head
working at:  Medical care: Neurostimulation
RP7 Clinical Research of Mental Disorders
RP3 Applied Neuroscience and Neuroimaging
in the institution:  2005 - present
telephone: (+420) 283 088 146
e-mail: monika.klirova@nudz.cz
curriculum vitae


PARTICIPATION IN SCIENTIFIC PROJECTS IN THE LAST  5 YEARS: 2013-2018

2012 - 2016   - PRVOUK P34 (The Charles University Research Development Schemes); Psychoneuropharmacological Research - participant

2012 - 2015 – grant IGA MH CZ No. NT13403 - The Role of mTOR (Mammalian Target of Rapamycin) Pathway in the Antidepressive Effect of Ketamine and Antidepressive Drugs in Patient with Depressive Disorder: Translation Study – participant 

2016 – 2019  - grant AZV CZ No. 16-31380A - Transcranial magnetic stimulation in the treatment of bipolar depression - co-worker

2017 -2020 – grant AZV CZ No. 1707070S - Effect of lithium on Na+/K+-ATPase activity and functional consequences of oxidative stress; from animal model to bipolar patients - co-worker

2017 – ong.   – PROGRESS Q 35 (The Charles University Research Development Schemes) - participant

 

 

Interests

PUBLIKAČNÍ AKTIVITA (publikace s IF)

Novak T, Horacek J, Mohr P, Kopecek M, Klirova M, Rodriguez M, Spaniel F, Dockery C, Hoschl C.The double-blind sham-controlled study of high-frequency rTMS (20Hz) for negative symptoms in schizophrenia: Negative results.Neuro Endocrinol Lett. 2006 Apr 25;27(1-2):209-213, IF 0,924, ISSN: 0172-780X

Horacek J, Dockery C,  Kopecek M, Spaniel F, Novak T, Tislerova B, Klirova M, Palenicek T, Hoschl C. Regional brain metabolism as the predictor of performance on the Trail Making Test in schizophrenia. A (18)FDG PET covariation study. Neuro Endocrinol Lett 2006;27:587-594. IF 0,924, ISSN: 0172-780X

Horacek J, Brunovsky M, Novak T, Skrdlantova L, Klirova M,  Bubenikova-Valesova V, Krajca V, Tislerova B, Kopecek M,  Spaniel F, Mohr P, Höschl C. Effect of Low-Frequency rTMS on Electromagnetic Tomography (LORETA) and Regional Brain Metabolism (PET) in Schizophrenia Patients with Auditory Hallucinations, Neuropsychobiology 2007;55:132-142 (DOI: 10.1159/000106055). IF 1.992, ISSN: 0302-282X

Klirova M, Novak T, Kopecek M, Mohr P, Strunzova V. Repetitive transcranial magnetic stimulation (rTMS) in major depressive episode during pregnancy: Neuroendocrinol Lett. 2008;29(1):69-70. IF 1,443, ISSN: 0172-780X

Spaniel F, Horacek J, Tintera J, Ibrahim I, Novak T, Cermak J, Klirova M, Hoschl C, Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients, Neuroscience Letters 2011;493(3):131-135. IF 1.925, ISSN: 0304-3940

Klirova M, Horacek J, Novak T, Spaniel F, Skrdlantova L, Mohr P, Höschl C,  Individualized rTMS neuronavigated according to regional brain metabolism (18FGD PET) has better treatment effects on auditory hallucinations than standard positioning of rTMS. A double-blind, sham-controlled study, Eur Arch Psychiatry Clin Neurosci 2013;263(6): 475-484, IF = 3.355, ISSN: 0940-1334. 

Fricova J, Klirova M, Masopust V, Novak T, Velebova K, Rokyta R, Repetitive transcranial magnetic stimulation in the treatment of chronic orofacial pain, Physiol. Res. 2013;62(Suppl 1):S125-S134, IF = 1.487, ISSN: 0862-8408.

Sos P., Klirova M., Novak T., Kohutova B., Horacek J., Palenicek T. Relationship of ketamine’s antidepressant and psychotomimetic effects in unipolar depression. Neuro. Endocrinol. Lett. 2013; 34: 287–293, IF = 0.935, ISSN: 0172-780X.

Kohútová B, Fricová J, Klírová M, Novák T, Rokyta R. Theta Burst Stimulation in the Treatment of Chronic Orofacial Pain: a Randomized Controlled Trial. Physiological Research. 2017;66(6):1041–1047. IF = 1,461, ISSN: 0862-8408.

Wagner E, Honer WG, Sommer IE, Koops S, Blumberger DM, Daskalakis Z, Dlabac-De Lange J, Bais L, Knegtering H, Aleman A, Novak T, Klirova M, Slotema C, Brunelin J, Poulet E, Kujovic M, Cordes J, Wobrock T, Siskind D, Falkai P, Schneider-Axmann T & Hasan A. Repetitive transcranial magnetic stimulation (rTMS) for schizophrenia patients treated with clozapine, The World Journal of Biological Psychiatry. 2020. DOI: 10.1080/15622975.1733080. IF = 4,225. Print ISSN: 1562-2975 Online ISSN: 1814-1412.

Klírová M., Hejzlar M., Kostýlková L., Mohr P., Rokyta R., Novák T. Prolonged Continuous Theta Burst Stimulation of the Motor Cortex Modulates Cortical Excitability but not Pain Perception. Front. Syst. Neurosci. doi: 10.3389/fnsys.2020.00027. IF = 3,928

Professional training and experience

2005 - 2013: Postdoctoral studies for PhD. in Neuroscience, Charles University, Prague
2005 - 2014: Clinical experience and scientific activity in Prague Psychiaric Center
2007 - 2007:
2007 - 2012:
2007 - present: Research activity at the 3rd Faculty of Medicine, Charles University, Prague
2010 - 2012: Head of the Laboratory of repetitive transcranial magnetic stimulation (rTMS), Prague Psychiatric Center
2012 - 2012:
2015 - present: Head of the department of Neurostimulation; Psychiatrist; Researcher; Psychoterapist in National Institute of Mental Health, Klecany

Membership in professional organizations

2006 - present: A member of the CNPS (The Czech Neuropsychopharmacological Corporation)
2013 - present: A member of the Psychiatric Society of the Czech Medical Association of J. E. Purkyně

Awards and honors

2007 - 2007: Awarded 1st poster presentation prize at the 15th Annual International Ain Shams Medical Students
2010 - 2010: Awarded ECNP Seminar Award 2010 during ECNP-EPA Seminar in Neuropsychopharmacology
2013 - 2013: The Award of Czech Neuropsychopharmacological Society for the best publication
2019 - 2019: The Award of Society of Biological Psychiatry for the best original work of the author up to 40 years of age

Specialization

2011 - 2011: Czech Board of Psychiatry
2012 - 2012: Czech Board of Psychotherapy
2013 - 2013: Postdoctoral studies in Neuroscience, Charles University, Prague

Teaching activities

2007 - present: Fellow for psychiatry at the 3rd Faculty of Medicine, Charles University, Prague

Publications

Most important publications

KLÍROVÁ, M., HORÁČEK, J., NOVÁK, T., ČERMÁK, J., ŠPANIEL, F., ŠKRDLANTOVÁ, L., MOHR, P., HÖSCHL, C. Individualized rTMS neuronavigated according to regional brain metabolism ((18)FGD PET) has better treatment effects on auditory hallucinations than standard positioning of rTMS: a double-blind, sham-controlled study. European Archives of Psychiatry and Clinical Neuroscience. 2013, 263(6), 475-484. ISSN 0940-1334. DOI: 10.1007/s00406-012-0368-x. IF 3.355.

KLÍROVÁ, M., NOVÁK, T., KOPEČEK, M., MOHR, P., STRUNZOVÁ, V. Repetitive transcranial magnetic stimulation (rTMS) in major depressive episode during pregnancy. Neuroendocrinology Letters. 2008, 29(1), 69-70. ISSN 0172-780X. IF 1.359.

WAGNER, E., HONER, WG., SOMMER, IE., KOOPS, S., BLUMBERGER, DM., DASKALAKIS, ZJ., DLABAC-DE LANGE, JJ., BAIS, L., KNEGTERING, H., ALEMAN, A., NOVÁK, T., KLÍROVÁ, M., SLOTEMA, Ch., BRUNELIN, J., POULET, E., KUJOVIC, M., CORDES, J., WOBROCK, T., SISKIND, D., FALKAI, P., SCHNEIDER-AXMANN, T., HASAN, A. Repetitive transcranial magnetic stimulation (rTMS) for schizophrenia patients treated with clozapine. World Journal of Biological Psychiatry. 2020, 2020(v tisku), 1-13. ISSN 1562-2975. DOI: 10.1080/15622975.2020.1733080. IF 4.164.

ŠPANIEL, F., HORÁČEK, J., TINTĚRA, J., IBRAHIM, I., NOVÁK, T., ČERMÁK, J., KLÍROVÁ, M., HÖSCHL, C. Genetic variation in FOXP2 alters grey matter concentrations in schizophrenia patients. Neuroscience Letters. 2011, 493(3), 131-135. ISSN 0304-3940. DOI: 10.1016/j.neulet.2011.02.024. IF 2.105.

HORÁČEK, J., BRUNOVSKÝ, M., NOVÁK, T., ŠKRDLANTOVÁ, L., KLÍROVÁ, M., BUBENÍKOVÁ-VALEŠOVÁ, V., KRAJČA, V., TIŠLEROVÁ, B., KOPEČEK, M., ŠPANIEL, F., MOHR, P., HÖSCHL, C. Effect of low-frequency rTMS on electromagnetic tomography (LORETA) and regional brain metabolism (PET) in schizophrenia patients with auditory hallucinations. Neuropsychobiology. 2007, 55(3-4), 132-142. ISSN 0302-282X. DOI: 10.1159/000106055. IF 1.992.


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