prof. Martin Alda, MD, FRCPC
researcher
working at:  RP3 Applied Neuroscience and Neuroimaging
in the institution:  2012 - present
telephone: (+420) 283 088 475
e-mail: martin.alda@nudz.cz
curriculum vitae


Senior researcher (part-time)

Professor of psychiatry and Killam Chair in Mood Disorders at Dalhousie University, and the head of the Mood Disorders Program at the QEII Health Sciences Centre

Dr. Alda received his medical degree from Charles University in Prague and trained in psychiatry at Charles University and at the University of Ottawa. His research focuses on three main areas:

1) mapping genes for bipolar disorder using innovative phenotypic approaches

2) better understanding of the brain structure and function in the development and progression of mood disorder

3) optimization of long-term treatment and outcome in people with bipolar disorder

Most relevant publications

Cruceanu C, Schmouth J-F, Torres-Platas SG, Lopez JP, Ambalavanan A, Darcq E, Gross F, Breton B, Spiegelman D, Rochefort D, Hince P, Petite JM, Gauthier J, Lafreniere RA, Dion PA, Greenwood CM, Kieffer BL, Alda M, Turecki G, Rouleau GA: Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors. Molecular Psychiatry, in press.

Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu Y-H, Shekhtman T, Adli M, Akula N, Ardau R, Arias B, Aubry J-M, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, Bengesser S, Biernackad JM, birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chillotti C, Cichon S, Colom F, Cruceanu C, Czerski PM, Dayer A, Del Zompo M, DePaulo JR, Étain B, Falkai P, Forstner AJ, Frisen L, Frye MA, Fullerton JM, Gard S, Garnham JS, Goes FS, Grigoroiu-Serbanescu M, Grof P, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn J-P, Kassem L, Kelsoe J, Kittel-Schneider S, Kliwicki S, König B, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Maj M, Manchia M, Martinsson L, McCarthy MJ, McElroy S, Mitchell PB, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen M, Novák T, O’Donovan C, Ösby U, Pfennig A, Potash JB, Reif A, Reininghaus E, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schweizer BW, Severino G, Shilling PD, Simhandl C, Slaney CM, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Vieta E, Volkert J, Witt S, Wright A, Zandi PP, Bauer M, Alda M, Rietschel M, McMahon FJ, Schulze TG, Baune BT: Association of polygenic score for Schizophrenia and HLA antigens and inflammation genes with response to lithium in Bipolar Affective Disorders. JAMA Psychiatry 75: 65 – 74, 2018.

Tobe BTD, Crain AM, Winquist AM, Calabrese B, Makihara H, Zhao W, Lalonde J, Nakamura H, Konopaske G, Sidor M, Pernia C, Yamashita N, Wada M, Inoue Y, Nakamura F, Sheridan SD, Logan R, Brandel M, Wu D, Hunsberger J, Dorsett L, Duerr C, Basa RCB, McCarthy M, Udeshi N, Mertins P, Carr SA, Rouleau G, Mastrangelo L, Li J, Gutierrez G, Brill LM, Venizelos N, Chen G, Nye JS, Manji H, Price J, McClung C, Akiskal HS, Alda M, Chuang DM, Coyle J, Liu Y, Teng Y, Ohshima T, Mikoshiba K, Sidman RL,  Halpain S, Haggarty SJ, Goshima Y, Snyder EY: Probing the lithium response pathway in hiPSCs implicates the phosphoregulatory setpoint for a cytoskeletal modulator in bipolar pathogenesis. Proceedings of the National Academy of Sciences of the United States 114: E4462 – E4471, 2017.

Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CEM, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chen G-B, Chen H-C, Chillotti C, Cichon S, Clark SR, Colom F, Cousins D, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Étain B, Falkai P, Forstner AJ, Frisén L, Fullerton JM, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn J-P, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, López Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy S, Mitjans, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller, JW, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus E, Novák T, Aubry J-M, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo P-H, Kato T, Grigoroiu-Serbanescu M, Reif A,  Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe J, Alda M, Rietschel M, McMahon FJ, Schulze TG: Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet 387: 1085 - 1093, 2016.

Mertens J, Wang QW, Kim Y, Yu DX, Pham S, Yang B, Zheng Y, Diffenderfer KE, Zhang J, Soltani S, Eames TJ, Schafer ST, Boyer L, Marchetto MC, Nurnberger JI, Calabrese JR, Odegaard KJ, McCarthy MJ, Zandi PP, Alda M, Nievergelt CM, The Pharmacogenomics of Bipolar Disorder Study, Mi S, Brennand KJ, Kelsoe JR, Gage FH, Yao J: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature 527: 95 - 99, 2015.

 


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