Neuroměsíčník: prof. Melvin G. McInnis – Phenomenology and common data models for integrative and comparative global research – 10. 4.

We would like to invite you to a talk in the lecture series „Neuroměsíčník“, organized by the Department of Psychiatry and Medical Psychology of the 3rd Faculty of Medicine of Charles University.

Phenomenology and common data models for integrative and comparative global research: the case for a Global Bipolar Cohort

prof. Melvin G. McInnis, MD, FRCPsych

April 10, 2024, 10.30 a.m. 

Höschl´s  Auditorium of NUDZ (National Institute of Mental Health), Topolová 748, Klecany, Czechia

What will be discussed?

Biological reductionism has, thus far, not succeeded in satisfying the need for etiological clarity in mental health conditions. Clinical phenomena remain, as noted by Jaspers a century ago, “ununderstandable”. The enthusiasm generated by the advances in genetics and the molecular technologies as well as neuroimaging resulted, overall, in diminished attention to phenomenology and the clinical features of psychiatric diseases. Sophisticated analyses are based on high-level categorical clinical impressions of the DSM or ICD and over 80% of the clinically nuanced phenomenological data are ‘dark’, unavailable for analysis. Herein a discussion and presentation on the current efforts behind the Global Bipolar Cohort collaborative and the researchers in the Human Phenotype Ontology consortium will address the need for a common data model based on clinical phenomenology. A strategy that includes the perspectives of Kraepelin and Jaspers along with recent efforts of the hierarchical taxonomy of psychopathology (HiTOP) and the research domain criteria (RDoC) will be reviewed.

Melvin McInnis is the Thomas B and Nancy Upjohn Woodworth Professor of Bipolar Disorder and Depression and the Director of the Heinz C Prechter Bipolar Research Program at the University of Michigan (U-M). He began his career in the genetics of bipolar disorder and presently leads a longitudinal research program in translational research focused on identifying underlying mechanisms behind bipolar disorder as well as characterizing clinical features that are predictive of the patterns of illness. Dr. McInnis trained in Canada, Iceland, London (UK), and Baltimore (Johns Hopkins). He is a Fellow of the American College of Neuropsychopharmacology (ACNP), the Royal College of Psychiatry (UK), and the Royal Society of Medicine (UK). Dr. McInnis leads the efforts to establish a global bipolar cohort (GBC), a collaborative of researchers and stakeholders focused longitudinal clinical research in bipolar disorder.

More information: 

This event is intended for interested professionals only.